Growth Factors in Periodontal Regeneration

Growth Factors in Periodontal Regeneration GROWTH FACTORS IN PERIODONTAL REGENERATION ABSTRACT : Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment fibers and supporting bone. Left untreated, these diseases can lead to tooth loss. The main cause of periodontal disease is a bacterial plaque, many options are available to treat this disease including non-surgical,surgical,and recent regenerative materials. GFs are natural biological mediators that regulate key cellular events that are part of the process of tissue repair and regeneration. Recent advances in the areas of cellular and molecular biology allowed better understanding of the functions of GFs and their participation in the different phases of wound healing. In vitro and in vivo studies have confirmed that GFs can enhance the capacity of tissues to regenerate by regulating cell chemo attraction, differentiation and proliferation. This review focuses on five growth factor families that have potential for inducing periodontal regeneration based on their ability to stimulate osteo blast and periodontal ligament cells in vivo and vitro. Key words: platelet-derived growth factor, insulin-like growth factor, transforming growth factor-beta, fibroblast growth factor, and bone morphogenetic protein. INTRODUCTION : Periodontitis is a widely prevalent inflammatory disease of the tissues supporting the teeth, characterized by a progressive loss of bone and attachment. The ultimate goal of periodontal therapy is the regeneration of periodontal tissues, which consists in stimulating new cementum formation, new alveolar bone apposition, and a functionally-oriented periodontal ligament reconstruction. Conventional treatment procedures may be ineffective in achieving bone regeneration, leaving both the clinician and the patient dissatisfied with the outcome. Growth factors (GFs) have long been believed to have the potential to accelerate the healing process and, therefore, enhance tissue regeneration in challenging clinical scenarios.1 MODE OF ACTION OF GROWTH FACTORS: To evoke a biologic effect, a growth factor must be synthesized by an originating cell, travel to its target receptor, interact with target receptor, or binding protein, and activate second messengers or terminal effectors.2,3 Local mode of action is more associated with the term growth factor and involves Paracrine, Autocrine, Juxtacrine, and Intracrine modes. Autocrine mode of action – Growth factors synthesized by one cell, secreted in a soluble form outside the cell and then bind to surface receptors on the same cell to evoke an effect is autocrine mode of action. Example includes: TGF ÃŽ ², which are produced and act on epithelial cells, and BMP’s, which are produced and act on osteoblastic cells. (fig 1) Intracrine mode of action–Growth factors produced by one cell and not secreted, but acts intracellularly to facilitate its effects is intracrine mode of action. (fig 2) Paracrine mode Growth factorsproduced by one cell, with receptors present on another cell in the local micro environment is the paracrine mode of action. Here the mediators are secreted in soluble form and binds to its receptors on the target cell to evoke its effect. (fig 3) Juxtacrine mode It is similar to paracrine effects except that the factor produced by the cell of origin is cell surface bound and requires cell contact by the target cell to evoke a response. (fig 4) RECEPTORS FOR GROWTH FACTORS:4,5 For a growth factor to exert an effect, its designated receptor must be present in sufficient quantity, orientation, and functional activity to transmit appropriate stimuli. Growth factor receptors can be divided into 2 broad categories: Cell surface receptors Intracellular receptors The most common prototype growth factor receptor is the cell surface receptor, which can be further divided into three main categories: G- protein linked Receptor tyrosine kinases Serine threonine receptor kinases POTENTIAL ROLES OF GROWTH FACTORS IN PERIODONTAL REGENERATION: To stimulate cell proliferation. E.g. Platelet derived growth factor (PDGF). To enhance function of cells and cell differentiation. E.g. Bone morphogenetic protein (BMP). To stimulate matrix synthesis. E.g. Transforming growth factor- ÃŽ ² (TGF- ÃŽ ²). To act as co-factors for gene expression. DISADVANTAGES OF GROWTH FACTORS: They were intended to be made by cells, stored than used locally. They have short half-lives i.e., when used as drug, doses must be greater than actual in vivo concentrations. They affect various cells in individual ways i.e., cells growing in high concentrations of growth factor had an increased susceptibility to cell death upon growth factor withdrawal. They need a delivery system for sustained or, controlled release (in low concentration) of a biologically active growth factor or, cocktail of growth factors. POLYPEPTIDE GROWTH FACTORS : Polypeptide growth factors are a diverse group of hormone-like agents that regulate growth and differentiation through cell surface receptors. They are generally represented by homologous families containing several members with distinct overlapping receptor interactions and hence, responsive tissue specificities. Similarly, their receptors are also clustered in family groups of sequence-related proteins. COMMON FEATURES OF POLYPEPTIDE GROWTH FACTORS :6 Natural cell products: Growth factors are natural cell products that are released or activated when cell division is needed.This action typically occurs during such events as wound healing or, tissue regeneration. Local actions: With few exceptions,growth factors are locally acting. Receptor activity: Because growth factors cannot diffuse across the cell membrane, growth factors must exert their activity by first binding to high-affinity cell membrane receptors.The capacity of a cell to respond to a given factor is therefore dependent on the presence of these receptors. Regulation: The production of polypeptide growth factors is tightly regulated in normal cells. In contrast, unregulated production of growth factor is thought to be an important component of proliferative disorders, such as fibrotic disease and cancers. Multifunctional activities: Polypeptide growth factors are multifunctional, meaning that they may stimulate a wide variety of cellular activities, which include growth, migration, differentiation and production of extracellular matrix proteins. Mechanism of action: In some cases, growth factors can stimulate the same cell that synthesizes the molecule (autocrine stimulation) or can affect nearby cells (paracrine stimulation). Regeneration: Tissue regeneration in vivo probably reflects the combined effect of several different growth factors. GROWTH FACTOR APPLICATIONS FOR ORAL AND PERIODONTAL TISSUE ENGINEERING : Therapeutic application of growth factors to restore damaged tissues aims at regeneration through biomimetic processes, or mimicking the processes that occur during embryonic and post-natal development.7 The complexity of these events suggests that creating an optimal regenerative environment requires the combination of different growth factors as found in natural reparative processes. The use of a single recombinant growth factor may also induce several molecular, biochemical and morphological cascades that will result in tissue regeneration.8 The most studied growth factors for periodontal regeneration have been PDGF, IGF, FGF-2, TGF-ÃŽ ² and different BMPs. SI. NO GROWTH FACTOR ALTERNATIVE NAMES SOURCE 1 Platelet-derived growth factor Fibroblast-derived growth factor. Glioma-derived growth factor Degranulating platelets Endothelial cells Smooth muscles Macrophages- Fibroblasts 2 Insulin-like growth factor Erythropoetic factor Growth-promoting activity for vascular endothelial cells Macrophages- Osteoblasts- Plasma stored in bone 3 Transforming growth factor-ÃŽ ² Epithelial cell specific growth inhibitor Tumour-inducing factor-1 Platelet ÃŽ ± granules 4 Fibroblast growth factor family Heparin binding growth factor Macrophage and osteoblasts stored in bone. PLATELET DERIEVED GROWTH FACTOR: The PDGFs are a family of dimeric disulfide – bound growth factors that exert their biologic effects by activating 2 structurally related tyrosine kinase receptors, the PDGF- ÃŽ ± and PDGF – ÃŽ ² receptors. PDGF was the first growth factor to be evaluated in preclinical periodontal and peri-implant regenerative studies. Proliferation, migration and matrix synthesis were observed on cultures of periodontal cells stimulated by PDGF, including gingival and PDL fibroblasts, cementoblasts, preosteo-blasts and osteoblastic cells [9-14]. These effects were shown to be time- and dose dependent 14. The PDGF family is composed of four growth factors: PDGF- A, -B, and the most recently discovered PDGF-C and -D 15. All of these participate in the wound-healing process, but, until now, only the three isoforms PDGF-AA, BB and AB were evaluated in periodontal therapy. PDGF-BB is the most effective on PDL cell mitogenesis and matrix biosynthesis 16,17. INSULIN LIKE GROWTH FACTOR: These are a family of single chain serum proteins that share 49% homology in sequence with pro- insulin. IGF-1 and IGF- 2 are two polypeptides from this group. IGF-1 acts as progression factor, also stimulates bone formation and have an effect on periodontal ligament cells. IGF-I is also important for bone remodeling and maintenance of skeletal mass and plays significant role in age-related osteoporosis. IGF-1 is capable of preventing apoptosis in fibroblasts by activation of multiple signal transduction pathways. IGF-1 has also been shown to regulate DNA and protein synthesis in periodontal ligament fibroblasts in vitro and to enhance soft tissue wound healing in vivo. Furthermore, studies have suggested variable responses of periodontal tissues to IGF-1 depending upon anatomical sites and a differential involvement of IGF-1 in periodontal wound healing and regeneration.18 FIBROBLAST GROWTH FACTOR: The angiogenic and fibroblast stimulatory properties of FGF-2 during wound healing and its chemotactic and proliferative effects on PDL cells suggest its use for periodontal regenerative therapeutic approaches19,20. In preclinical studies, this growth factor was evaluated for the treatment of different types of periodontal bone defects, in dogs and non-human primates. Despite different concentrations of FGF-2 and different delivery systems used in the studies, all showed an improvement in the periodontal tissue regeneration, compared with control groups. Studies that evaluated more than one concentration of FGF-2 suggested that its effects are dose dependent.21,22 TRANSFORMING GROWTH FACTOR ÃŽ ²: It is a member of a large family of biologically active protein hormones that are structurally related but differ markedly in their function. TGF ÃŽ ² consists of 2 subunits held together by covalent bonds. Five different genes are identified that encodes TGF- ÃŽ ² polypeptide TGF-ÃŽ ² has 5 closely related isoforms in vertebrates, out of which 3 are found in mammals (TGF-ÃŽ ²1, TGF-ÃŽ ²2, TGF-ÃŽ ²3). The three major activities of TGF-ßinclude inhibition of cell proliferation, enhancement of extracellular matrix deposition and the exhibition of complex immune regulatory properties. It is a major regulator of cell replication and differentiation. It can stimulate or inhibit cell growth. It can also modulate other growth factors like PDGF, EGF and FGF. It inhibits epithelial cell proliferation and stimulates mesenchymal cells. TGF-ÃŽ ²1, the most abundant isoform of the TGF-ÃŽ ² family and found primarily in the platelets and osseous tissue, has been used for this application.It has a role in recruiting and stimulating osteoprogenitor cells to proliferate and suggests to support periodontal wound healing and regeneration.23 BONE MORPHOGENETIC PROTEINS: The name Bone Morphogenetic Protein was given in 1965 by Urist .Bone morphogenetic proteins (BMPs) are a group of regulatory glycoproteins that are members of the transforming growth factor-beta superfamily.24They stimulate angiogenesis and migration, proliferation and differentiation of mesenchymal stem cells into cartilage and bone forming cells. More than 20 BMP-related proteins have been identified, several of which induce bone formation.25 In the field of periodontal regeneration, much of the research interest has focused on BMP-2, BMP-3 (osteogenin), and BMP-7. Recent studies have utilized recombinant human BMP to determine their potential for correcting intrabony, supra-alveolar, furcation, and fenestration defects. BMPs also show much promise in promoting dental implant wound healing.24 GROWTH FACTOR DELIVERY SYSTEMS: Several matrices and delivery systems have been used and evaluated for their efficacy and biocompatibility as carrier for growth factors. Two common types of polymeric materials used in growth factor delivery strategies are natural collagen-derived materials and synthetic polymers of lactic and glycolic acid (i.e., Poly [lactide-co-glycolide]). Extracellular matrix-derived macromolecules such as collagen have been used for many years in biomaterial application, and it is now possible to create artificial analogues of extracellular matrix proteins using recombinant DNA technology.1 Carriers can be of different types such as solids, gels or combinations.25A variety of new injectable materials such as hydrogels are also being developed for growth factor delivery applications and have been of special interest. These injectables are especially attractive because, in clinical application, they can allow for minimally invasive delivery of inductive molecules.1 CONCLUSION: Growth factors may regulate the repair and/or regenerative process which are impaired in presence of bacteria and their products in periodontal disease. Thus, the objective of growth factors administration in the treatment of periodontitis is to mimic the normal developmental process enhance normal wound healing response to promote complete regeneration of all attachment structures. Basic and clinical research is in progress to evaluate the role of growth factors in periodontal wound healing. BIBLIOGRAPHY: DARNELL KAIGLER, GUSTAVO AVILA, LESLIE WISNER-LYNCH, MARC L. NEVINS, MYRON NEVINS, GIULIO RASPERINI. Platelet-Derived Growth Factor Applications in Periodontal and Peri-Implant Bone Regeneration .Expert OpinBiolTher. 2011 March ; 11(3): 375–385 RIPAMONTI U, HERBST NN, RAMOSHEBI LN. Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: experimental studies in the non-human primate Papioursinus. Cytokine Growth Factor Rev 2005;16(3):357–368. ANUSAKSATHIEN O, GIANNOBILE WV. Growth factor delivery to re-engineer periodontal tissues. Curr. Pharm. Biotechnol 2002;3(2):129–139. FRECHETTE JP, MARTINEAU I, GAGNON G.Platelet-rich plasmas: growth factor content and roles in wound healing. J Dent Res 2005; 84(5): 434-439. LAURIE K. MC CAULEY MARTHA J. Somerman. Biologic modifiers in periodontal regeneration. Dent Clin N Am , Advances in Periodontics, part I 1998; 43(2): 361-387. GARRY R. GROTENDORST. Connective tissue growth factor : A mediator of TGF- ÃŽ ² action on fibroblasts. Mini Review. Cytokine and growth factor reviews 1997, 8(3); 171 – 179. SCHILEPHAKE H. Bone growth factors in maxillofacial skeletal reconstruction. Int. J. Oral Maxillofac. Surg 2002;31(5):469–484. RIPAMONTI U, HERBST NN, RAMOSHEBI LN. Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: experimental studies in the non-human primate Papioursinus. Cytokine Growth Factor Rev 2005;16(3):357–368. NISHIMURA F, TERRANOVA VP. Comparative study of the chemotactic responses of periodontal ligament cells and gingival fibroblasts to polypeptide growth factors. J. Dent. Res 1996;75(4):986–992. SAYGIN NE, TOKIYASU Y, GIANNOBILE WV, SOMERMAN MJ. Growth factors regulate expression of mineral associated genes in cementoblasts. J. Periodontol 2000;71(10):1591–1600. STRAYHORN CL, GARRETT JS, DUNN RL, BENEDICT JJ, SOMERMAN MJ. Growth factors regulate expression of osteoblast-associated genes. J. Periodontol 1999;70(11):1345–1354. CANALIS E. Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria. Metabolism 1981;30(10):970–975. BARTOLD PM, RABEN A. Growth factor modulation of fibroblasts in simulated wound healing. J.Periodontal Res 1996;31(3):205–216. OJIMA Y, MIZUNO M, KUBOKI Y, KOMORI T. In vitro effect of platelet-derived growth factor-BB on collagen synthesis and proliferation of human periodontal ligament cells. Oral Dis 2003;9(3): 144–151. REIGSTAD LJ, VARHAUG JE, LILLEHAUG JR. Structural and functional specificities of PDGFC and PDGF-D, the novel members of the platelet-derived growth factors family. FEBS J 2005;272 (22):5723–5741. BOYAN LA, BHARGAVA G, NISHIMURA F, et al. Mitogenic and chemotactic responses of human periodontal ligament cells to the different isoforms of platelet-derived growth factor. J. Dent. Res 1994;73(10):1593–1600. MATSUDA N, LIN WL, KUMAR NM, CHO MI, GENCO RJ. Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J.Periodontol 1992;63(6):515–525. XIAOZHE HAN AND SALOMON AMAR. Role of Insulin-Like Growth Factor-1 Signaling in Dental Fibroblast Apoptosis. J Periodontol 2003;74:1176-1182. TAKAYAMA S, MURAKAMI S, MIKI Y, et al. Effects of basic fibroblast growth factor on human periodontal ligament cells. J. Periodontal Res 1997;32(8):667–675. TERRANOVA VP, ODZIEMIEC C, TWEDEN KS, SPADONE DP. Repopulation of dentin surfaces by periodontal ligament cells and endothelial cells. Effect of basic fibroblast growth factor. J. Periodontol 1989;60(6):293–301. ROSSA C JR. MARCANTONIO E Jr, CIRELLI JA, et al. Regeneration of class III furcation defects with basic fibroblast growth factor (b-FGF) associated with GTR. A descriptive and histometric study in dogs. J. Periodontol 2000;71(5):775–784. TAKAYAMA S, MURAKAMI S, SHIMABUKURO Y, KITAMURA M, OKADA H. Periodontal regeneration by FGF-2 (bFGF) in primate models. J. Dent. Res 2001;80(12):2075–2079. KI-TAE KOO,CRISTIANO SUSIN, ULF M.E. WIKESJOÂ ¨, SEONG-HO CHOI, AND CHONG-KWAN KIMI. Transforming Growth Factor-b1 Accelerates Resorption of a Calcium Carbonate Biomaterial in Periodontal Defects. J Periodontol 2007;78:723-729. KARUPPANAN P. SASIKUMAR, SUGUMARI ELAVARASU, AND JAYAPRAKASH S. GADAGI. The application of bone morphogenetic proteins to periodontal and peri-implant tissue regeneration: A literature review. J Pharm Bioallied Sci. Aug 2012; 4(Suppl 2): S427–S430. SUBRAMANIAM M RAO, GAURI M UGALE, AND SHIVARAJ B WARAD. Bone Morphogenetic Proteins: Periodontal Regeneration. N Am J Med Sci. Mar 2013; 5(3): 161–168.

Free College Admissions Essays - MS Will Not Kill My Dream :: College Admissions Essays

MS Will Not Kill My Dream My story with MS began on December 4, 1999. I arrived at school as usual that cold winter morning feeling pretty good, a little tired, but other wise ok. Upon parking my car and opening the door to get out my right arm went to "sleep." I was totally blown away by it. How bizarre I thought to myself and just sat there a moment trying to figure out what possibly could be wrong with my arm. The next two days brought no relief and if anything it seemed to be getting more intense. My WHOLE arm was asleep and I just couldn't understand it. I visited a chiropractor a couple of days later and she said I was dehyrdrated and that my nervous system was under attack. Little did I know! I became increasingly concerned as the days passed and just couldn't buy what everyone was telling me, that I had a pinched nerve. I just knew it was something more and it was! I found a doctor about two weeks later and by that time my right hand was barely useable and the right side of my face, head and chest had also gone numb. I was scared to death! This doctor was wonderful and immediatly ran tests, sent me to a specialist, (neurologist) and spent hours with me examining me and trying to figure out just what could be wrong with me! MS never crossed my mind. A nurse of over ten years I have taken care of only ONE MS patient, a lady in her 90's! MS just didnt occur to me. After several visits to the neurologist, MRI, spinal tap and a slew of blood work I was told that MS was VERY likely the culprit. I was, to say the least, devastated by this news. I cried and cried and greived over this. It was with great fortune that a lady I worked with became extremly helpful to me during this time and prayed for me, listened to me and on more than one occasion, let me cry on her shoulder. On March 4, 2000 I visited a MS specialist at Dartmouth Hitchcock Hospital in Lebanon N.H. and he made it official that it was MS and immediatly started me on Avonex. At this point I had researched the disease endlessly, somewhat come to terms with this awful fate and began to think more positively.

On Pathography

Why do humans write them? Robert Maunder, a physicists and professor, illustrates an essay called, â€Å"On Photography,† that presents meta-commentary stories In Body & Soul. The genre of literature called, â€Å"photography,† describes his essay and Interest about being sick. Maunder establishes terms such as battle, triumph and survivor to reflect on the narratives of Illness. He describes his essay through elements of critical thinking by clarity, evidence of support and assumptions underlying the argument. As a result, Robert Maunder clearly manifest his main proposal successfully.Maunder expresses the clarity of his main argument of photography through his beliefs. For several of patients, to triumph over sickness, signifies an important part of the experience. The best photographers, in Maunders eyes, are those â€Å"like the best novels and poems, {he} suppose, describe life with subtlety contradiction, emotion, depth, beauty and banality. But it helps to read the best† (Maunder, 2004). Sometimes, the most efficient teaching lad Is to analyze and read written accounts of one's aspect from sickness or facing death as It can receive empathy towards one another.Patients who are diagnosed with a terminal Illness can evoke fear, depression and anger. However, Maunder also believes that the best photographers are those â€Å"who are curious and unashamed enough to write about what illness has done to their minds and preferences and relationships† (Maunder, 2004). It indicates that the existential truth is a familiar Indus of reflection for a sick writer, which the author compares to personal victory. The capability of understanding and connecting tit one and another is faint. Maunder argues how â€Å"a critically ill person needs above all is to be understood.Dying is a misunderstanding that you have to get straightened out before you go† (Maunder, 2004). Sickness cannot be acknowledged for understanding, until your friends and family, with love, recognize the absolute knowledge of your chronic disease. Thus, the clarity of his main argument Is pushed by his beliefs. He contributes his mall argument through personal observations, reflection, and anecdotes, as he not only try to convince the reader, but also himself. Maunder uses personal observation with his patients and students by reading photographers of other authors.He begins with Robert Mason Lee's photography, of his pain of Chronic disease, where his audience was conveyed by â€Å"the experience of that particular pain very well to someone who has never felt it. † (Maunder, 2004). He explains how a powerful writer has the unique ability to express their connections to feelings and awaken our senses. These senses are within others and us, where it results to think in synthesizing ways. Maunder also uses personal, short and amusing vents to account his message across.For example, he has read â€Å"few other essays where the author Is so c ompletely alive and present In the text, in all his narcissistic, gleeful, annoying, contemplative splendor,† such as Anatoly Broad (Maunder, 2004). Board's wrote a photography called, â€Å"Intoxicated by My Illness,† as he was dying of prostate cancer. This photography captivated Maunder eye's due to his bright and insightful personality, where did not take sickness as a serious event, but by convinced that â€Å"illness is a test of relationship, of values, and of faith-but as Job caches us, it is a test that, once passed, continues nonetheless† (Maunder, 2004).Illness and life are similar. However, illness can render as the greatest destroyer of denial where it has the power to reach a person's soul negatively. These personal experiences assist Maunders main argument. Maunder also apply his assumptions to propel his argument forward. He postulates how humans view their morality is recognized. He believes how â€Å"the battle metaphor of destruction is not ap propriate in this instance either. What serious illness does to denial is make it obvious† (Maunder, 004).Young children, teenagers and adults, are almost always solipsistic, that it affects their worldview. A sickness is Just to overcome, whereas older people, it becomes more of a challenge because they dwell on it, which can consume them. As a result, it changes their mindsets for the worst. Maunder continues his assumptions for how the society views on morality by providing the idea that one can truly live when they are faced with a death crisis. He brings â€Å"another version of the hope for redemption through illness† (Maunder, 2004).Maunder imagines his hopes for others who have suffered through illnesses, where it might illuminate certain situations and help gain perspective. For a while, Maunder takes a step back from writing illness narratives and explores into the genre of literature, consisting of stories regarding the aspects of sick patients. He argues tha t â€Å"triumphant battles, how much they actually do convey an important part of the experience of being sick for many people,† is an expectation (Maunder, 2004). Humans, who struggle with chronic illness(s), are the toughest of the tough.They are able to continually face the struggles of life and battle a debilitating disease than those who appear to live with it. Consequently, Maunder takes granted for people who lack of the knowledge of being sick to drive his topic ahead. In summary, Robert Maunder proves his main idea thoroughly and distinctly. He uses clarity, evidence for support and assumptions to underlie the principle of the argument. Maunder narrates photographers about being sick and communicates an extraordinary manner to an incomprehensible audience who Just needs to understand.

Japanese Female Apparel Market For Japanese Women Essay

While the bubbly outfits with overflowing laces and floral patterns that highlight the soft and sensitive characteristics once dominated the female apparel market in Japan, nowadays, Japanese women prefer balancing out the femininity with some stylish mannish clothing. Figure 3, where the woman matched her black lace dress and high heels with an olive-green military jacket, perfectly exemplifies the chic â€Å"甘è ¾â€ºÃ£Æ'ŸãÆ'Æ'ã‚ ¯Ã£â€š ¹Ã£â€š ³Ã£Æ' ¼Ã£Æ'‡â€  (The sweet-and-sexy coordinates) adored by many Japanese female consumers. The concept of â€Å"甘è ¾â€ºÃ£Æ'ŸãÆ'Æ'ã‚ ¯Ã£â€š ¹Ã¢â‚¬  is so well received in Japan because it spices up the overall look with an exquisite aesthetic balance. Known for wanting to break away from the mainstream, young Japanese female quickly adopted MA-1 jacket and the â€Å"girly-military look† as a mean to expressive their individualism in contradiction to social norms. As a result, MA-1 jacket has slowly become a wardrobe staple for Japanese young women. Another significant aspect of MA-1 jacket that helps it secure its top-ranked position is its ability to â€Å"casual down† a dressy outfit. Directly translated from the Japanese-made English word, ã‚ «Ã£â€š ¸Ã£Æ' ¥Ã£â€š ¢Ã£Æ' «Ã£Æ'€ã‚ ¦Ã£Æ' ³, â€Å"casualing-down† coordinates means to dress-down, or to break down the formality of fancy clothing (FASHION PRESS). A notable change in style has swept over Japan when people began to embrace apparels that value both comfort and personal style. According to a survey conducted by Jiratanatiteenun, Mizutani, Sato, Kitaguchi, and Kajiwara in 2011, â€Å"Casual [style] was theShow MoreRelatedUniqlo Assessment Presentation and Project Report Environmental Analysis Apparel Brand Management1066 Words   |  5 PagesIntroduction UNIQLO was a Japanese apparel brand under UNIQLO Co., Ltd established in 1974. They offered â€Å"MADE FOR ALL† high quality causal wear at competitive price. The firm had earned a huge success and high reputation. 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Leading in the ‘new wave’ of 80s Japan fashion alongside Rei Kawakubo, Issey Miyake and other designers, Yamamoto marked a brand that was inherently defiant and acutely fluid, putting pieces on the runway that accentuated the space between fabric and skin rather than condensedRead MoreMotorcycle Industry Analysis1271 Words   |  6 Pagesup almost half of their business through sales of parts, accessories, and apparel. In 1997 approximately 6.5 million motorcycles were owned in the United States, with California having almost two times more retail outlets than any other state. In terms of rider distribution, California, Texas, New York, Florida, and Ohio accounted for more than one-third of all motorcycle ownership in the U.S. In terms of a target market there seems to be no specific or clear differentiation. Below are some statisticsRead MoreForever 21 Marketing Plan4752 Words   |  20 PagesForever 21 Marketing Plan ïÆ' ¼ Index 1. Executive Summary†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦3 2. Environmental Analysis†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦.3 2.1 Apparel Market Analysis†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦.3 2.2 Competitive Analysis†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢ € ¦.†¦5 2.3 SWOT Analysis†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.7 3. Objectives†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦10 4. Marketing Strategies†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦12 5. Detailed Action Plan†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Read MoreStanding Tall: Japan’s Resilient Luxury Market5129 Words   |  21 PagesResilient Luxury Market Brian Salsberg Naomi Yamakawa Photograph: Abbie Chessler 2 In the immediate aftermath of the tsunami, earthquake and nuclear disaster that hit Japan last year, killing 19,000 people and battering the nation’s already shaky confidence, it was hardly surprising that people didn’t feel like shopping. At the time, the conventional wisdom was that such restraint was likely to last. People would still have to shop for essentials, of course, but the market for things like